Plaa Gene Summary [Mouse]
Enables phospholipase A2 activator activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; positive regulation of dendrite extension; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Acts upstream of or within inflammatory response. Located in cytoplasm; nucleus; and synapse. Part of cytoplasmic ubiquitin ligase complex. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plaa |
| Official Name | phospholipase A2, activating protein [Source:MGI Symbol;Acc:MGI:104810] |
| Ensembl ID | ENSMUSG00000028577 |
| Bio databases IDs | |
| Aliases | phospholipase A2, activating protein |
| Synonyms | 2410007N06, D4Ertd618e, DOA1, NDMSBA, phospholipase A2 activating protein, phospholipase A2, activating protein, PLA2 activating, PLA2P, PLAP, Ufd3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plaa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUL domain
- phospholipase A2 activator
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- PFU (PLAA family ubiquitin binding)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with progressive microcephaly spasticity and brain anomalies
- hereditary disorder
- schizophrenia
role in cell
- expression in
- activation in
- response
- production in
- extension
- migration by
- recycling
- macroautophagy in
- damage in
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plaa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of protein K63-linked ubiquitination
- nervous system development
- prostaglandin metabolic process
- phospholipid metabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- inflammatory response
- cellular response to lipopolysaccharide
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- positive regulation of phospholipase A2 activity
- ubiquitin homeostasis
- macroautophagy
- positive regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phospholipase A2 activator activity