Magoh Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction subcomplex mago-y14. Is expressed in intestine; liver; spleen; telencephalon; and testis. Orthologous to human MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magoh |
| Official Name | mago homolog, exon junction complex core component [Source:MGI Symbol;Acc:MGI:1330312] |
| Ensembl ID | ENSMUSG00000028609 |
| Bio databases IDs | |
| Aliases | mago homolog, exon junction complex core component |
| Synonyms | MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit, Mago-m, Mos2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Magoh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mago nashi proteins, integral members of the exon junction complex
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- gastric adenocarcinoma
- gastric epithelial cancer
- gastric cancer
- metastasis
- hypopigmentation
role in cell
- expression in
- survival
- phosphorylation in
- binding in
- migration
- proliferation
- invasion by
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Magoh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- mRNA export from nucleus
- RNA splicing
- regulation of mRNA processing
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- catalytic step 2 spliceosome
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding