Dhx8 Gene Summary [Mouse]
Predicted to enable RNA binding activity; RNA helicase activity; and identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear body. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhx8 |
| Official Name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 [Source:MGI Symbol;Acc:MGI:1306823] |
| Ensembl ID | ENSMUSG00000034931 |
| Bio databases IDs | |
| Aliases | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
| Synonyms | DDX8, DEAH-box helicase 8, Dhr2, HRH1, LRRGT00035, mDEAH6, mKIAA4096, PRP22, PRPF22, Putative RNA helicase homolog, RNA helicase HRH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhx8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Ribosomal protein S1-like RNA-binding domain
- S1_like
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- helicase superfamily c-terminal domain
- GIPC homology 2 (GH2) domain-like family
- enzyme
- protein binding
- RNA dependent ATPase
- identical protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- Helicase associated domain (HA2) Add an annotation
- S1 RNA binding domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- liver cancer
- lung cancer
- Dupuytren contracture
- metabolic syndrome X
- acute myeloid leukemia
role in cell
- expression in
- cell viability
- processing in
- splicing by
- replication in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- cytosol
- spliceosomes
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhx8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spliceosomal complex disassembly
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- catalytic step 2 spliceosome
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- cytosol
- intracellular
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- RNA binding
- RNA helicase activity
- RNA-dependent ATPase activity