Srek1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srek1 |
| Official Name | splicing regulatory glutamine/lysine-rich protein 1 [Source:MGI Symbol;Acc:MGI:2145245] |
| Ensembl ID | ENSMUSG00000032621 |
| Bio databases IDs | |
| Aliases | splicing regulatory glutamine/lysine-rich protein 1 |
| Synonyms | 8430401B01, AL118220, SFRS12, splicing regulatory glutamic acid and lysine rich protein 1, splicing regulatory glutamine/lysine-rich protein 1, SRrp508, SRrp86, Srsf12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srek1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutamic acid-lysine rich domain
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- SR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srek1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding