Akr1a1

Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate and cellular detoxification of aldehyde. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane. Is active in cytosol and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Akr1a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Akr1a1 gene, providing context for its role in the cell.