Nsun4 Gene Summary [Mouse]
Enables small ribosomal subunit rRNA binding activity. Involved in cytosolic ribosome assembly; positive regulation of mitochondrial translation; and rRNA methylation. Located in mitochondrion. Is expressed in several structures, including branchial arch; central nervous system; limb bud; neural ectoderm; and sensory organ. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsun4 |
| Official Name | NOL1/NOP2/Sun domain family, member 4 [Source:MGI Symbol;Acc:MGI:1919431] |
| Ensembl ID | ENSMUSG00000028706 |
| Bio databases IDs | |
| Aliases | NOL1/NOP2/Sun domain family, member 4 |
| Synonyms | 2310010O12Rik, 2810405F18Rik, LOC103690007, NOL1/NOP2/Sun domain family, member 4, NOP2/Sun RNA methyltransferase 4, RGD1559652, SHTAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsun4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA methyltransferase
- rRNA (cytosine-C5-967)-methyltransferase
- rRNA binding
- NOL1/NOP2/sun family putative RNA methylase
- RNA methyltransferase
- 16S rRNA methyltransferase RsmB/F
- enzyme
- protein binding
- AdoMet_MTases
- mRNA methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsun4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrial large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- rRNA (cytosine-C5-)-methyltransferase activity
- rRNA methyltransferase activity
- protein binding
- tRNA (cytosine-5-)-methyltransferase activity
- methyltransferase activity
- rRNA binding