Rpl18 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is expressed in brain. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl18 |
| Official Name | ribosomal protein L18 [Source:MGI Symbol;Acc:MGI:98003] |
| Ensembl ID | ENSMUSG00000059070 |
| Bio databases IDs | |
| Aliases | ribosomal protein L18 |
| Synonyms | DBA18, eL18, L18, LOC108167423, ribosomal protein L18, Rpl18a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein 60S L18 and 50S L18e
- structural constituent of ribosome
- PRK04005
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Diamond-Blackfan anemia type 18
- systemic autoimmune syndrome
- infection by Marburg virus
- infection by Zaire ebolavirus
- infection by HIV-1
regulates
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- ribosome
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoli
- nuclear envelope
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- focal adhesion
- cytoplasm
- membrane
- rough endoplasmic reticulum
- cytosol
- endoplasmic reticulum
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome