Aurkaip1 Gene Summary [Mouse]
Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of proteolysis and protein ubiquitination. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human AURKAIP1 (aurora kinase A interacting protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aurkaip1 |
| Official Name | aurora kinase A interacting protein 1 [Source:MGI Symbol;Acc:MGI:1913327] |
| Ensembl ID | ENSMUSG00000065990 |
| Bio databases IDs | |
| Aliases | aurora kinase A interacting protein 1 |
| Synonyms | 0610033H09RIK, AIP, AKIP, aurora kinase A interacting protein 1, MRP-S38, mS38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aurkaip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal domain of Arabidopsis thaliana At5g63150 and similar proteins
- ubiquitin-protein transferase activity
- nuclear localization sequence
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- breast cancer
- HER2 negative hormone receptor negative breast cancer
- insulin resistance
regulated by
- calcitriol
- SOD1
- HuH7 cells
role in cell
- apoptosis
- degradation in
- cell death
- proliferation
- survival
- migration
- ubiquitination in
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aurkaip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- mitochondrial translation
- positive regulation of proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- mitochondrial small ribosomal subunit
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding