Rbfox1 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Acts upstream of or within neuromuscular process controlling balance; regulation of alternative mRNA splicing, via spliceosome; and regulation of skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; cranial nerve; heart; peripheral nervous system ganglion; and retina. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbfox1 |
| Official Name | RNA binding protein, fox-1 homolog (C. elegans) 1 [Source:MGI Symbol;Acc:MGI:1926224] |
| Ensembl ID | ENSMUSG00000008658 |
| Bio databases IDs | |
| Aliases | RNA binding protein, fox-1 homolog (C. elegans) 1 |
| Synonyms | 2BP1, A2bp, A2BP1, FOX-1, HRNBP1, LOC100287538, RNA binding fox-1 homolog 1, RNA binding protein, fox-1 homolog (C. elegans) 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbfox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin gene-related peptide regulator C terminal
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- chronic obstructive pulmonary disease
- COVID-19
- rubella
- gout
- schizophrenia
- refractive error
- insomnia
- major depression
- hyperopia
role in cell
- expression in
- alternative splicing by
- excitability
- alternative splicing in
- depolymerization in
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum/Golgi apparatus fractions
- polyribosome fractions
- ribonucleoprotein granule
- perinuclear region
- Nucleus
- cytosol
- trans Golgi network
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbfox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- nervous system development
- RNA transport
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear stress granule
- trans-Golgi network
- cytoplasmic stress granule
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding