Nipal3 Gene Summary [Mouse]
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; central nervous system; ganglia; genitourinary system; and nasal cavity epithelium. Orthologous to human NIPAL3 (NIPA like domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Nipal3 |
| Official Name | NIPA-like domain containing 3 [Source:MGI Symbol;Acc:MGI:1921802] |
| Ensembl ID | ENSMUSG00000028803 |
| Bio databases IDs | |
| Aliases | NIPA-like domain containing 3 |
| Synonyms | 9130020G22RIK, AI480660, DJ462O23.2, LOC683962, NIPA-like domain containing 3, NPAL3, RGD1563439, SLC57A5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nipal3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EamA-like transporter family
- protein binding
- Magnesium transporter NIPA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- glioblastoma
- glioblastoma cancer
- abnormality of the integument
regulated by
- YAP1
- THZ531
regulates
- IgM
- Immunoglobulin
- IgA
- IgE
- IgG2a
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nipal3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- magnesium ion transport
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- magnesium ion transmembrane transporter activity