Rspo1 Gene Summary [Mouse]
Enables heparin binding activity and signaling receptor binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; genitourinary system; and integumental system. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rspo1 |
| Official Name | R-spondin 1 [Source:MGI Symbol;Acc:MGI:2183426] |
| Ensembl ID | ENSMUSG00000028871 |
| Bio databases IDs | |
| Aliases | R-spondin 1 |
| Synonyms | CRISTIN3, Mgi:2183426, RGD1565558, RSPO, R-spondin, R-spondin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rspo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 domain
- FU
- G-protein-coupled receptor binding
- Furin-like repeat, cysteine-rich
- heparin binding domain
- Furin-like repeats
- protein binding
- receptor binding
- Spondin-like TSP1 domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian carcinoma
- serous ovarian cancer
- epithelial ovarian cancer
- preeclampsia
- serous ovarian adenocarcinoma
- palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal
- pseudohermaphroditism
- tumorigenesis
- open-angle glaucoma
role in cell
- apoptosis
- phosphorylation in
- expression in
- formation
- accumulation in
- signaling in
- growth
- number
- expansion
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rspo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of receptor internalization
- positive regulation of protein phosphorylation
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- heparin binding
- receptor binding