RSPO1 Gene Summary [Human]
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | RSPO1 |
| Official Name | R-spondin 1 [Source:HGNC Symbol;Acc:HGNC:21679] |
| Ensembl ID | ENSG00000169218 |
| Bio databases IDs | |
| Aliases | R-spondin 1 |
| Synonyms | CRISTIN3, Mgi:2183426, RGD1565558, RSPO, R-spondin, R-spondin 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RSPO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 domain
- FU
- G-protein-coupled receptor binding
- Furin-like repeat, cysteine-rich
- heparin binding domain
- Furin-like repeats
- protein binding
- receptor binding
- Spondin-like TSP1 domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian carcinoma
- serous ovarian cancer
- epithelial ovarian cancer
- preeclampsia
- serous ovarian adenocarcinoma
- palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal
- pseudohermaphroditism
- tumorigenesis
- open-angle glaucoma
role in cell
- apoptosis
- phosphorylation in
- expression in
- formation
- accumulation in
- signaling in
- growth
- number
- expansion
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RSPO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of receptor internalization
- positive regulation of protein phosphorylation
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- heparin binding
- receptor binding