Taf12 Gene Summary [Mouse]
Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in early conceptus; limb; oocyte; and tail. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf12 |
| Official Name | TATA-box binding protein associated factor 12 [Source:MGI Symbol;Acc:MGI:1913714] |
| Ensembl ID | ENSMUSG00000028899 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 12 |
| Synonyms | 2810422D08Rik, TAF2J, TAFII20, TATA-box binding protein associated factor 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-activator
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- DNA binding
Pathways
Biological processes and signaling networks where the Taf12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chromosomal instability
role in cell
- checkpoint recovery in
- transactivation in
- mitotic entry in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- transcription initiation, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- TBP-class protein binding