Nfya Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfya |
| Official Name | nuclear transcription factor-Y alpha [Source:MGI Symbol;Acc:MGI:97316] |
| Ensembl ID | ENSMUSG00000023994 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor-Y alpha |
| Synonyms | CBF-A, CBF-B, FLJ11236, HAP2, LOC100129914, NFY, nuclear transcription factor-Y alpha, nuclear transcription factor Y subunit alpha, nuclear transcription factor Y subunit α, nuclear transcription factor-Y α, Nuclear transcription factor y, α, isoform 1, Nuclear transcription factor y, α, isoform 2, SEZ-10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfya often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Pst domain
- transcription factor binding
- HAP2 domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
- double-stranded DNA binding
- heterodimerization domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfya gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- organismal death
- acute myeloid leukemia
- gastric epithelial cancer
- allergic rhinitis
- hepatoid gastric adenocarcinoma
role in cell
- quantity
- growth
- migration
- expression in
- sphere formation
- apoptosis
- production in
- cell cycle progression
- differentiation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfya gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhythmic process
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity