Ntn3 Gene Summary [Mouse]
Enables signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to act upstream of or within myoblast fusion and regulation of DNA-templated transcription. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and tooth. Orthologous to human NTN3 (netrin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntn3 |
| Official Name | netrin 3 [Source:MGI Symbol;Acc:MGI:1341188] |
| Ensembl ID | ENSMUSG00000117406 |
| Bio databases IDs | |
| Aliases | netrin 3 |
| Synonyms | netrin 3, NTN2L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- protein binding
- receptor binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Ntn3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Golgi Apparatus
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axon guidance
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity