Ntn1 Gene Summary [Mouse]
Predicted to be an extracellular matrix structural constituent. Involved in chemorepulsion of axon and regulation of synapse assembly. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and regulation of neurogenesis. Located in basement membrane and cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lung; and sensory organ. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntn1 |
| Official Name | netrin 1 [Source:MGI Symbol;Acc:MGI:105088] |
| Ensembl ID | ENSMUSG00000020902 |
| Bio databases IDs | |
| Aliases | netrin 1 |
| Synonyms | BC019633, MRMV4, NET1, Netrin-1, NTN1L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin domain VI
- NTR_like
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- laminin V-like domain
- protein binding
- laminin VI-like domain
- growth factor
- EGF repeat
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Ntn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Parkinson disease
- motor dysfunction
- obesity
- colorectal adenocarcinoma
- cleft palate
- cleft lip
- colorectal carcinomagenesis
- reperfusion injury
- stuttering
role in cell
- apoptosis
- expression in
- activation in
- formation in
- proliferation
- production in
- cell death
- growth
- phosphorylation in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- periaxonal myelin membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cell periphery
- actin cytoskeleton
- Plasma Membrane
- cytosol
- nucleoplasm
- neurites
- synapse
- membrane processes
- perikaryon
- excitatory synapses
- basement membrane
- axolemmal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of glial cell proliferation
- nuclear migration
- mammary gland duct morphogenesis
- Ras protein signal transduction
- positive regulation of axon extension
- substrate-dependent cell migration, cell extension
- regulation of transcription from RNA polymerase II promoter
- negative regulation of axon extension
- apoptotic process
- inner ear morphogenesis
- Cdc42 protein signal transduction
- anterior/posterior axon guidance
- glial cell proliferation
- regulation of synapse assembly
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- basement membrane
- actin cytoskeleton
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity