Dnajc2 Gene Summary [Mouse]
Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin-modified histone reader activity. Acts upstream of or within DNA replication and negative regulation of DNA biosynthetic process. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; blastocyst; brain; hemolymphoid system gland; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc2 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C2 [Source:MGI Symbol;Acc:MGI:99470] |
| Ensembl ID | ENSMUSG00000029014 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C2 |
| Synonyms | DnaJ heat shock protein family (Hsp40) member C2, MIDA1, MPHOSPH11, MPP11, ZRF1, Zrf2, ZUO1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- SANT
- histone binding
- transcription regulator
- Hsp70 protein binding
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- protein binding activity, bridging
- chromatin binding
- protein binding
- Ribosome-associated complex head domain
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- MAP7 (E-MAP-115) family
- Myb-like DNA-binding domain
Pathways
Biological processes and signaling networks where the Dnajc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational fidelity
- positive regulation of transcription, DNA-dependent
- regulation of cellular response to heat
- DNA replication
- 'de novo' cotranslational protein folding
- chromatin organization
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- histone binding
- ribosome binding
- chromatin binding
- ATPase activator activity
- Hsp70 protein binding