Prkci Gene Summary [Mouse]
Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of D-glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and brush border. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkci |
| Official Name | protein kinase C, iota [Source:MGI Symbol;Acc:MGI:99260] |
| Ensembl ID | ENSMUSG00000037643 |
| Bio databases IDs | |
| Aliases | protein kinase C, iota |
| Synonyms | 2310021H13Rik, APKC, aPKC IOTA/LAMBDA, aPKC lambda, aPKC ι/λ, aPKC λ, DXS1179E, mKIAA4165, nPKC-iota, nPKC-ι, PKCI, PKC IOTA, Pkcl, PKC LAMBDA, Pkc lamda, Pkc lamda/iota, Pkc lamda/ι, PKC tau, PKC-ι, PKC λ, PRKCL, protein kinase C iota, protein kinase C, iota, protein kinase C ι, protein kinase C, ι |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkci often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- calcium independent protein kinase C
- protein binding
- Protein kinase domain
- PB1
- Phox and Bem1 domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- pseudosubstrate domain
- protein kinase C
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkci gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- Fc Epsilon RI Signaling
- fMLP Signaling in Neutrophils
- Glioma Signaling
- Growth Hormone Signaling
- Hepatic Cholestasis
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- gastric carcinoma
- metastatic breast cancer
- metastasis
- lung squamous cell carcinoma
- ovarian cancer
- cancer
- adenoma formation
- epithelial neoplasia
role in cell
- expression in
- growth
- phosphorylation in
- activation in
- quantity
- apoptosis
- cell death
- proliferation
- cell viability
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- low-density microsomal fraction
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- cell periphery
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- centrosome
- cell-cell contacts
- cytoplasmic bridges
- cytosol
- microsome
- apical membrane
- nucleoplasm
- nerve ending
- synapse
- Schmidt-Lanterman incisures
- myoplasm
- tight junctions
- junctional complexes
- brush border
- cell membrane leading edge
- mitotic spindle
- axons
- plasma
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkci gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of apical/basal cell polarity
- cytoskeleton organization
- negative regulation of glial cell apoptotic process
- actin filament organization
- protein phosphorylation
- positive regulation of Notch signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of neuron apoptotic process
- cellular response to insulin stimulus
- vesicle-mediated transport
- establishment or maintenance of epithelial cell apical/basal polarity
- positive regulation of neuron projection development
- positive regulation of endothelial cell apoptotic process
- cell migration
- intracellular signal transduction
- membrane organization
- secretion
- positive regulation of glial cell proliferation
- eye photoreceptor cell development
- positive regulation of glucose import
- protein targeting to membrane
- cell-cell junction organization
- negative regulation of apoptotic process
- response to interleukin-1
- peptidyl-serine phosphorylation
- Golgi vesicle budding
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell leading edge
- Golgi membrane
- plasma membrane
- nucleoplasm
- nucleus
- tight junction
- occluding junction
- intercellular bridge
- extracellular vesicular exosome
- endosome
- brush border
- Schmidt-Lanterman incisure
- cytosol
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- phospholipid binding
- protein serine/threonine kinase activity
- protein kinase C activity