Tchp Gene Summary [Mouse]
Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tchp |
| Official Name | trichoplein, keratin filament binding [Source:MGI Symbol;Acc:MGI:1925082] |
| Ensembl ID | ENSMUSG00000002486 |
| Bio databases IDs | |
| Aliases | trichoplein, keratin filament binding |
| Synonyms | A930031F18RIK, AV279199, RGD1310813, TpMs, TRICHOPLEIN, trichoplein keratin filament binding, trichoplein, keratin filament binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tchp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trichohyalin-plectin-homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- coronary artery disease
- myocardial infarction
- metabolic syndrome X
role in cell
- accumulation in
- production in
- growth
- apoptosis
- differentiation
- formation
- degradation in
- formation in
- size
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- ciliary transition fiber
- cilia
- cell periphery
- apical compartment
- cell cortex
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- desmosomes
- cell-cell contacts
- cytosol
- nuclear envelope
- apical cortex
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tchp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- apoptotic process
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- keratin filament
- cytoplasm
- mitochondrion
- cytosol
- apical cortex
- desmosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding