Pank4 Gene Summary [Mouse]
Predicted to enable pantothenate kinase activity and phosphatase activity. Predicted to be involved in coenzyme A biosynthetic process and coenzyme A catabolic process. Predicted to be active in cytosol; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Used to study cataract. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pank4 |
| Official Name | pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2387466] |
| Ensembl ID | ENSMUSG00000029056 |
| Bio databases IDs | |
| Aliases | pantothenate kinase 4 |
| Synonyms | CTRCT49, D030031I12Rik, Fang1, Gm42363, pantothenate kinase 4, pantothenate kinase 4 (inactive) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pank4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fumble
- Damage-control phosphatase ARMT1-like domain
- pantothenate kinase
- phosphatase
- pantothenate kinase, eukaryotic/staphyloccocal type
- enzyme
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pank4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pantothenate metabolic process
- coenzyme A biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- phosphatase activity
- pantothenate kinase activity