Ppm1g Gene Summary [Mouse]
Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study schizophrenia. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1g |
| Official Name | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform [Source:MGI Symbol;Acc:MGI:106065] |
| Ensembl ID | ENSMUSG00000029147 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform |
| Synonyms | Fin13, PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, protein phosphatase 1G (formerly 2C), magnesium-dependent, γ isoform, Protein phosphatase 2c γ, protein phosphatase, Mg2+/Mn2+ dependent 1G, protein phosphatase, Mg2+/Mn2+ dependent, 1G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine phosphatase
- protein phosphatase
- phosphoprotein phosphatase
- phosphatase
- protein binding
Pathways
Biological processes and signaling networks where the Ppm1g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary genetic hyperlipidemia
role in cell
- phosphorylation in
- growth
- survival
- binding in
- translation in
- accumulation
- JQ1-sensitivity
- dephosphorylation in
- cell cycle progression
- heterodimerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- protein dephosphorylation
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity