Cgref1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to be located in extracellular region. Is expressed in several structures, including bone; forelimb; heart ventricle; nervous system; and urinary system. Orthologous to human CGREF1 (cell growth regulator with EF-hand domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cgref1 |
| Official Name | cell growth regulator with EF hand domain 1 [Source:MGI Symbol;Acc:MGI:1915817] |
| Ensembl ID | ENSMUSG00000029161 |
| Bio databases IDs | |
| Aliases | cell growth regulator with EF hand domain 1 |
| Synonyms | 1110004G24Rik, Cell growth regulator with EF-hand domain, cell growth regulator with EF-hand domain 1, CGR11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cgref1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- attention deficit hyperactivity disorder
- colorectal cancer
- vascular dementia
- infection by HIV-1
role in cell
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cgref1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- cell adhesion
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding