Ctsf Gene Summary [Mouse]
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in adrenal gland and blood vessel. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsf |
| Official Name | cathepsin F [Source:MGI Symbol;Acc:MGI:1861434] |
| Ensembl ID | ENSMUSG00000083282 |
| Bio databases IDs | |
| Aliases | cathepsin F |
| Synonyms | Cathepsin F, CATSF, CLN13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- cysteine endopeptidase
- Cathepsin propeptide inhibitor domain (I29)
- peptidase
- Peptidase_C1
- protein binding
Pathways
Biological processes and signaling networks where the Ctsf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neuronal ceroid lipofuscinosis
- neuronal ceroid lipofuscinosis type 13
- hereditary disorder
- weight loss
- high-grade squamous intraepithelial lesion
- tremor
- neurodevelopmental disorder
- cachexia
- cervical carcinoma
- epithelial uterine cancer
regulates
- LDL
- MHC II (complex)
- APOB
- Collagen type I (complex)
- Z-Phe-Arg-AMC
role in cell
- growth
- abnormal morphology
- antigen presentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- lysosome
- Endoplasmic Reticulum
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- lysosomal lumen
- endoplasmic reticulum
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- cysteine-type endopeptidase activity