Agbl5 Gene Summary [Mouse]
Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in defense response to virus and protein deglutamylation. Located in cytosol and nucleus. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agbl5 |
| Official Name | ATP/GTP binding protein-like 5 [Source:MGI Symbol;Acc:MGI:2441745] |
| Ensembl ID | ENSMUSG00000029165 |
| Bio databases IDs | |
| Aliases | ATP/GTP binding protein-like 5 |
| Synonyms | 9430057O19Rik, AGBL carboxypeptidase 5, ATP/GTP binding protein-like 5, CCP5, RP75 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agbl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- peptidase
- metallocarboxypeptidase
- Cytosolic carboxypeptidase N-terminal domain
- M14 family of metallocarboxypeptidases and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- retinal dystrophy
- autosomal recessive retinitis pigmentosa
- teratozoospermia
- retinitis pigmentosa type 75
- retinitis pigmentosa
- oligozoospermia
- infection by HIV-1
regulated by
- mir-22 (includes others)
regulates
- tubulin (family)
- tubulin
role in cell
- formation
- abnormal morphology
- polyglutamylation
- polyglutamylation in
- deglutamylation in
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- Nucleus
- midbody
- cytoplasmic bridges
- cytosol
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agbl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deglutamylation
- C-terminal protein deglutamylation
- proteolysis
- defense response to virus
- protein side chain deglutamylation
- protein branching point deglutamylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- intercellular bridge
- mitotic spindle
- cytoplasm
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- metallocarboxypeptidase activity