Prps2 Gene Summary [Mouse]
Enables ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and pentose-phosphate shunt. Is active in cytosol. Is expressed in alimentary system; central nervous system; heart; liver; and retina. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prps2 |
| Official Name | phosphoribosyl pyrophosphate synthetase 2 [Source:MGI Symbol;Acc:MGI:97776] |
| Ensembl ID | ENSMUSG00000025742 |
| Bio databases IDs | |
| Aliases | phosphoribosyl pyrophosphate synthetase 2 |
| Synonyms | 2610101M19Rik, LOC100910245, phosphoribosyl pyrophosphate synthetase 2, PRSII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prps2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP binding
- ribose-phosphate diphosphokinase
- ATP binding
- ATP phosphoribosyltransferase
- Phosphoribosyl transferase (PRT)-type I domain
- Phosphoribosyl synthetase-associated domain
- protein binding
- magnesium ion binding
- N-terminal domain of ribose phosphate pyrophosphokinase
- identical protein binding
- PRK00934
- kinase
- AMP binding
- GDP binding
- protein homodimerization
- ribose-phosphate pyrophosphokinase
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
regulates
- AMP
- phosphoribosyl pyrophosphate
- nucleic acid component or derivative
role in cell
- proliferation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prps2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside monophosphate biosynthetic process
- purine nucleotide biosynthetic process
- pentose-phosphate shunt
- nucleobase-containing compound metabolic process
- 5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- ribose phosphate diphosphokinase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- ribose phosphate diphosphokinase activity
- kinase activity