Dhx15 Gene Summary [Mouse]
Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in antiviral innate immune response and defense response to bacterium. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Is expressed in several structures, including aorta; forelimb bud; future brain; liver; and spleen. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhx15 |
| Official Name | DEAH (Asp-Glu-Ala-His) box polypeptide 15 [Source:MGI Symbol;Acc:MGI:1099786] |
| Ensembl ID | ENSMUSG00000029169 |
| Bio databases IDs | |
| Aliases | DEAH (Asp-Glu-Ala-His) box polypeptide 15 |
| Synonyms | DBP1, DD15, DDX15, DEAH9, DEAH-box helicase 15, hPrp43, HRH2, LOC100910750, mDEAH9, PRP43, PRPF43, PrPp43p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhx15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- RNA dependent ATPase
- Helicase conserved C-terminal domain
- RNA helicase
- RNA binding
- Helicase associated domain (HA2) Add an annotation
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- COVID-19
- schizophrenia
- pathologic myopia
- infection by HIV-1
regulated by
- AKT1
- imatinib
- poly rI:rC-RNA
- arsenic trioxide
- tretinoin
- FSH
- corticosteroid
- interferon alfacon-1
- UT-143
- gabapentin
role in cell
- growth
- phosphorylation in
- production in
- splicing by
- processing in
- reverse transcription in
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhx15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- defense response to virus
- response to alkaloid
- mRNA processing
- response to toxin
- defense response to bacterium
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- U12-type spliceosomal complex
- nuclear speck
- spliceosomal complex
- nucleolus
- intracellular
- U2-type post-mRNA release spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity
- double-stranded RNA binding
- RNA-dependent ATPase activity
- helicase activity