Enam Gene Summary [Mouse]
A structural constituent of tooth enamel. Acts upstream of or within several processes, including ameloblast differentiation; amelogenesis; and positive regulation of enamel mineralization. Located in extracellular matrix. Is expressed in jaw. Used to study amelogenesis imperfecta type 1B. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1B and amelogenesis imperfecta type 1C. Orthologous to human ENAM (enamelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enam |
| Official Name | enamelin [Source:MGI Symbol;Acc:MGI:1333772] |
| Ensembl ID | ENSMUSG00000029286 |
| Bio databases IDs | |
| Aliases | enamelin |
| Synonyms | abte, ADAI, AI1C, AIH2, Enamelin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Enam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of tooth enamel
- Enamelin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amelogenesis imperfecta type IB
- amelogenesis imperfecta type IC
- amelogenesis imperfecta
phenotypes
- improved glucose tolerance
- abnormal ameloblast morphology
- abnormal compact bone morphology
- abnormal digestion
- abnormal enamel mineralization
- abnormal enamel morphology
- abnormal enamel organ morphology
- abnormal enamel rod pattern
- abnormal enzyme/coenzyme activity
- abnormal incisor color
- abnormal incisor morphology
- abnormal lower incisor color
- abnormal lower incisor morphology
- abnormal molar crown morphology
- abnormal molar cusp morphology
- abnormal molar morphology
- abnormal mouth morphology
- abnormal tooth attrition
- abnormal tooth mineralization
- abnormal tooth morphology
- abnormal tooth wear
- abnormal trabecular bone morphology
- abnormal upper incisor color
- abnormal upper incisor morphology
- absent Tomes' process
- absent enamel
- decreased body length
- decreased body mass index
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating cholesterol level
- decreased circulating transferrin level
- decreased circulating triglyceride level
- decreased compact bone area
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin concentration distribution width
- decreased total body fat amount
- delayed tooth eruption
- increased alkaline phosphatase activity
- increased lean body mass
- increased mean corpuscular volume
- mandibular cysts
- maxillary cysts
- premature tooth eruption
- reduced enamel thickness
role in cell
- differentiation
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Enam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- amelogenesis
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of tooth enamel