Enam Gene Summary [Rat]
Predicted to be a structural constituent of tooth enamel. Predicted to be involved in ameloblast differentiation; amelogenesis; and positive regulation of enamel mineralization. Predicted to act upstream of or within odontogenesis of dentin-containing tooth and regulation of cell morphogenesis. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1B and amelogenesis imperfecta type 1C. Orthologous to human ENAM (enamelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enam |
| Official Name | enamelin [Source:RGD Symbol;Acc:1306796] |
| Ensembl ID | ENSRNOG00000003672 |
| Bio databases IDs | |
| Aliases | enamelin |
| Synonyms | abte, ADAI, AI1C, AIH2, Enamelin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Enam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of tooth enamel
- Enamelin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Enam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- amelogenesis
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of tooth enamel