ENAM Gene Summary [Human]
Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | ENAM |
| Official Name | enamelin [Source:HGNC Symbol;Acc:HGNC:3344] |
| Ensembl ID | ENSG00000132464 |
| Bio databases IDs | |
| Aliases | enamelin |
| Synonyms | abte, ADAI, AI1C, AIH2, Enamelin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENAM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of tooth enamel
- Enamelin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENAM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- amelogenesis
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of tooth enamel