Bgn Gene Summary [Mouse]
This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Bgn |
| Official Name | biglycan [Source:MGI Symbol;Acc:MGI:88158] |
| Ensembl ID | ENSMUSG00000031375 |
| Bio databases IDs | |
| Aliases | biglycan |
| Synonyms | BG, Biglycan, BSPG1, DSPG1, MRLS, PGI, PG-S1, SEMDX, SLRR1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- protein phosphatase 1 regulatory subunit 42
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix binding
- Leucine rich repeat
- protein binding
- Leucine rich repeat N-terminal domain
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- adenoma formation
- weight gain
- osteoarthritis
- mucoepidermoid carcinoma
- gastric cancer
- Meester-Loeys syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- rheumatoid arthritis
role in cell
- binding
- phosphorylation in
- activation in
- apoptosis
- proliferation
- expression in
- quantity
- accumulation
- cellular infiltration by
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- intracellular space
- Nucleus
- lysosomal compartment
- synapse
- sarcolemma
- transport vesicles
- extracellular matrix
- motor endplates
- cartilage matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- sarcolemma
- lysosomal lumen
- transport vesicle
- extracellular matrix
- Golgi lumen
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- glycosaminoglycan binding
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix structural constituent
- cytokine binding