Crybb1 Gene Summary [Rat]
A structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Human ortholog(s) of this gene implicated in cataract and cataract 17 multiple types. Orthologous to human CRYBB1 (crystallin beta B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crybb1 |
| Official Name | crystallin, beta B1 [Source:RGD Symbol;Acc:2416] |
| Ensembl ID | ENSRNOG00000047653 |
| Bio databases IDs | |
| Aliases | crystallin, beta B1 |
| Synonyms | 3110006K12Rik, BB1CRY, beta B1 CRYSTALLIN, CATCN3, CRYB1, CRYB11, crystallin beta B1, crystallin, beta B1, crystallin β B1, crystallin, β B1, CTRCT17, β B1 CRYSTALLIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crybb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- Peptidase inhibitor family I36
- protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive congenital nuclear cataract type 3
- nuclear cataract 17 with microcornea
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- high myopia
- congenital cataract
regulates
role in cell
- solubilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crybb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- visual perception
- lens development in camera-type eye
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of eye lens