Mad1l1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and kinetochore binding activity. Acts upstream of or within negative regulation of T cell proliferation; regulation of mitotic cell cycle phase transition; and thymus development. Located in cytoplasm; kinetochore; and spindle pole. Part of MAD1 complex and mitotic spindle assembly checkpoint MAD1-MAD2 complex. Is expressed in brain; cerebral cortex; future brain; hippocampus; and telencephalon. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mad1l1 |
| Official Name | MAD1 mitotic arrest deficient 1-like 1 [Source:MGI Symbol;Acc:MGI:1341857] |
| Ensembl ID | ENSMUSG00000029554 |
| Bio databases IDs | |
| Aliases | MAD1 mitotic arrest deficient 1-like 1 |
| Synonyms | hMAD1, HSMAD1, LOC686419, MAD1, MAD1-like 1, MAD1 mitotic arrest deficient 1-like 1, mitotic arrest deficient 1 like 1, MVA7, PIG9, TP53I9, TXBP181 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mad1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Mad2 binding domain
- transcription repression domain
- binding protein
- nuclear localization sequence
- coiled-coil domain
- leucine zipper domain
- protein binding
- basic domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- schizoaffective disorder
- schizophrenia
- neoplasia
- depressive disorder
- anxiety disorder
- non-insulin-dependent diabetes mellitus
- hypertension
- breast cancer
- coronary artery disease
role in cell
- proliferation
- quantity
- growth
- apoptosis
- activation in
- migration
- formation
- formation in
- expansion
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- Golgi Apparatus
- midbody
- cytosol
- spindle pole
- nuclear envelope
- nuclear scaffolds
- mitotic spindle
- kinetochores
- chromatin
- kinetochore corona
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mad1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle spindle assembly checkpoint
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- regulation of metaphase plate congression
- negative regulation of T cell proliferation
- thymus development
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- centrosome
- mitotic spindle
- spindle
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- kinetochore binding
- identical protein binding
- protein binding