Cdk2 Gene Summary [Mouse]
Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of nucleobase-containing compound metabolic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk2 |
| Official Name | cyclin-dependent kinase 2 [Source:MGI Symbol;Acc:MGI:104772] |
| Ensembl ID | ENSMUSG00000025358 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 2 |
| Synonyms | A630093N05Rik, CDC2-RELATED KINASE, CDKN2, Cyclin A associated kinase, cyclin dependent kinase 2, CYCLIN E ASSOCIATED KINASE, p33(CDK2) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- protein kinase
- catalytic domain
- protein domain specific binding
- enzyme
- protein binding
- magnesium ion binding
- Protein kinase domain
- phosphorylation site
- cyclin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- active site
- cyclin-binding domain
Pathways
Biological processes and signaling networks where the Cdk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Aryl Hydrocarbon Receptor Signaling
- ATM Signaling
- Cell Cycle Control of Chromosomal Replication
- Cell Cycle Regulation by BTG Family Proteins
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- GADD45 Signaling
- HGF Signaling
- IL-7 Signaling Pathway
- Molecular Mechanisms of Cancer
- p53 Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Serotonin Receptor Signaling
- Small Cell Lung Cancer Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- congestive heart failure
- neoplasia
- infertility condition
- bleeding
- stenosis
- abdominal cancer
- digestive system cancer
- epithelial cancer
- cancer
role in cell
- proliferation
- expression in
- differentiation
- activation in
- cell death
- growth
- phosphorylation in
- apoptosis
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear membrane
- perinuclear region
- Plasma Membrane
- endosomes
- centrosome
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear envelope
- Cajal bodies
- neurites
- telomeres
- X chromosome
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- centriole replication
- DNA replication
- positive regulation of cell proliferation
- cellular senescence
- positive regulation of DNA replication
- protein phosphorylation
- post-translational protein modification
- telomere maintenance in response to DNA damage
- potassium ion transport
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- chromatin remodeling
- meiotic cell cycle
- G2/M transition of mitotic cell cycle
- positive regulation of transcription, DNA-dependent
- G1/S transition of mitotic cell cycle
- positive regulation of heterochromatin assembly
- cellular response to nitric oxide
- transcription, DNA-dependent
- mitotic cell cycle G1/S transition DNA damage checkpoint
- signal transduction
- Ras protein signal transduction
- regulation of mitotic cell cycle
- centrosome duplication
- regulation of gene expression
- positive regulation of DNA-dependent DNA replication initiation
- peptidyl-serine phosphorylation
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- Y chromosome
- X chromosome
- cyclin-dependent protein kinase holoenzyme complex
- Cajal body
- male germ cell nucleus
- nucleoplasm
- nuclear envelope
- condensed chromosome
- chromosome, telomeric region
- transcription factor complex
- nucleus
- cyclin A2-CDK2 complex
- cyclin E2-CDK2 complex
- centrosome
- cyclin A1-CDK2 complex
- endosome
- cyclin E1-CDK2 complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein domain specific binding
- protein binding
- histone kinase activity
- cyclin binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity