Lhx5 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription and spinal cord association neuron differentiation. Acts upstream of or within cerebellar Purkinje cell-granule cell precursor cell signaling; nervous system development; and regulation of neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including future brain; limb; nervous system; sensory organ; and urinary system. Orthologous to human LHX5 (LIM homeobox 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhx5 |
| Official Name | LIM homeobox protein 5 [Source:MGI Symbol;Acc:MGI:107792] |
| Ensembl ID | ENSMUSG00000029595 |
| Bio databases IDs | |
| Aliases | LIM homeobox protein 5 |
| Synonyms | Lim2, LIM homeobox 5, LIM homeobox protein 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Lhx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
role in cell
- proliferation
- quantity
- expression in
- differentiation
- migration
- guidance
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
- neuroblast proliferation
- cerebellar Purkinje cell differentiation
- cell proliferation in forebrain
- positive regulation of transcription, DNA-dependent
- neuron differentiation
- spinal cord association neuron differentiation
- forebrain neuron differentiation
- hippocampus development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity