Gad1 Gene Summary [Mouse]
The protein encoded by this gene is an enzyme that catalyzes the production of gamma-aminobutyric acid from L-glutamic acid. Alternative splicing of this gene results in three products, the predominant 67 kDa isoform, a smaller 25 kDa isoform, and an even smaller 49 aa isoform. The two shorter isoforms are not thought to retain catalytic activity. [provided by RefSeq, Apr 2023]
Details
| Type | Protein Coding |
| Official Symbol | Gad1 |
| Official Name | glutamate decarboxylase 1 [Source:MGI Symbol;Acc:MGI:95632] |
| Ensembl ID | ENSMUSG00000070880 |
| Bio databases IDs | |
| Aliases | glutamate decarboxylase 1 |
| Synonyms | CPSQ1, DEE89, EP10, GAD, GAD67, glutamate decarboxylase 1, Glutamic acid decarboxylase, SCP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aminotransferase class-V
- glutamate decarboxylase
- pyridoxal phosphate binding
- binding protein
- AAT_I
- glutamate binding
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Gad1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- GABA Receptor Signaling
- Gap Junction Signaling
- Neuroinflammation Signaling Pathway
- Relaxin Signaling
- Synaptic Long Term Depression
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- developmental and epileptic encephalopathy type 89
- palatal shelves fail to meet at midline
- schizophrenia
- heat hyperalgesia
- bipolar disorder
- heroin dependence
- hyperammonemia
- pervasive developmental disorder
- hypoxia
role in cell
- quantity
- migration
- proliferation
- synaptic transmission in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- presynaptic regions
- perinuclear region
- cell cortex
- Plasma Membrane
- vesicles
- cytosol
- neurites
- nerve ending
- synaptosomes
- synapse
- perikaryon
- axons
- postsynaptic density
- axon terminals
- presynaptic terminals
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate catabolic process
- social behavior
- locomotory exploration behavior
- synaptic transmission
- glutamate decarboxylation to succinate
- gamma-aminobutyric acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
- presynaptic active zone
- cytoplasm
- vesicle membrane
- cell cortex
- axon terminus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- identical protein binding
- protein binding
- glutamate decarboxylase activity