Ldb2 Gene Summary [Mouse]
Enables enzyme binding activity. Involved in regulation of cell migration and regulation of kinase activity. Acts upstream of or within several processes, including epithelial structure maintenance; hair follicle development; and positive regulation of transcription by RNA polymerase II. Located in cell leading edge. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; eye; genitourinary system; limb; and nervous system. Orthologous to human LDB2 (LIM domain binding 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldb2 |
| Official Name | LIM domain binding 2 [Source:MGI Symbol;Acc:MGI:894670] |
| Ensembl ID | ENSMUSG00000039706 |
| Bio databases IDs | |
| Aliases | LIM domain binding 2 |
| Synonyms | AI035351, AW146358, CLIM1, CLP-36, LDB1, Ldb3, LIM domain binding 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM-domain binding
- transcription regulator
- transcription cofactor
- enzyme binding
- protein binding
- LIM-domain binding protein
- LIM interaction domain (LID)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- insomnia
- rhegmatogenous retinal detachment
- abdominal aortic aneurysm
- androgenic alopecia
- diabetic nephropathy
- plaque psoriasis
- organismal death
- COVID-19
- lung cancer
role in cell
- activation in
- expression in
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- nucleoli
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ldb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- negative regulation of transcription from RNA polymerase II promoter
- cellular component biogenesis
- hair follicle development
- epithelial structure maintenance
- positive regulation of cellular component biogenesis
- somatic stem cell maintenance
- nervous system development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cell leading edge
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- LIM domain binding
- enzyme binding