Rpl6 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Is expressed in several structures, including genitourinary system; intestine; liver; lung; and spleen. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl6 |
| Official Name | ribosomal protein L6 [Source:MGI Symbol;Acc:MGI:108057] |
| Ensembl ID | ENSMUSG00000029614 |
| Bio databases IDs | |
| Aliases | ribosomal protein L6 |
| Synonyms | 60s ribosomal, eL6, L6, Ribosomal protein l6, SHUJUN-2, TAXREB107, TXREB1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- Ribosomal protein L6e
- structural constituent of ribosome
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- rRNA binding
- mRNA binding
- protein binding
- Ribosomal protein L6, N-terminal domain
- DNA binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- acute myeloid leukemia
- papillary thyroid carcinoma
- papillary thyroid cancer
- myelodysplastic syndrome
- diabetes mellitus
regulates
- cyclin E
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cellular membrane
- ribosome
- Nucleus
- sarcomere
- cytosol
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- regulation of transcription, DNA-dependent
- ribosomal large subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- rough endoplasmic reticulum
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- structural constituent of ribosome
- cadherin binding