Ndufa4 Gene Summary [Mouse]
Predicted to be involved in positive regulation of cytochrome-c oxidase activity. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa4 |
| Official Name | Ndufa4, mitochondrial complex associated [Source:MGI Symbol;Acc:MGI:107686] |
| Ensembl ID | ENSMUSG00000029632 |
| Bio databases IDs | |
| Aliases | Ndufa4, mitochondrial complex associated |
| Synonyms | CI-9k, CI-MLRQ, Complex I-MLRQ, COXFA4, LOC679503, LOC681024, MC4DN21, MISTR1, MLRQ, MRCAF1, Nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4, Nadh dehydrogenase (ubiquinone) 1 α subcomplex 4, NDUA4, NDUFA4 mitochondrial complex associated, Ndufa4, mitochondrial complex associated |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufa4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- NADH2 dehydrogenase
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- NADH-ubiquinone reductase complex 1 MLRQ subunit
Pathways
Biological processes and signaling networks where the Ndufa4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- neoplasia
- septic shock
- Leigh syndrome
- insulin resistance
- metabolic syndrome X
- Huntington disease
- organismal death
- adult acute myeloid leukemia
- nuclear type 21 mitochondrial complex IV deficiency
role in cell
- expression in
- transmembrane potential
- proliferation
- production in
- mitochondrial respiration in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufa4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial membrane
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase (ubiquinone) activity