Lmod2 Gene Summary [Mouse]
Predicted to enable actin monomer binding activity and tropomyosin binding activity. Involved in actin filament polymerization and sarcomere organization. Predicted to be located in actin filament; cardiac myofibril; and sarcomere. Predicted to be active in striated muscle thin filament. Predicted to colocalize with M band. Is expressed in several structures, including aorta; central nervous system; foregut; heart; and skeletal musculature. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G. Orthologous to human LMOD2 (leiomodin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmod2 |
| Official Name | leiomodin 2 (cardiac) [Source:MGI Symbol;Acc:MGI:2135672] |
| Ensembl ID | ENSMUSG00000029683 |
| Bio databases IDs | |
| Aliases | leiomodin 2 (cardiac) |
| Synonyms | C-LMOD, CMD2G, leiomodin 2, leiomodin 2 (cardiac), LOC100909784, LOC154866 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmod2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin monomer binding
- actin binding
- tropomyosin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- actin filaments
- sarcomere
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmod2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- pointed-end actin filament capping
- muscle contraction
- actin nucleation
- actin filament polymerization
- positive regulation of actin filament polymerization
- sarcomere organization
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- cytoskeleton
- M band
- actin filament
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin binding
- tropomyosin binding
- actin monomer binding