Tmod1 Gene Summary [Mouse]
Enables tropomyosin binding activity. Involved in lens fiber cell development. Acts upstream of or within adult locomotory behavior; muscle contraction; and myofibril assembly. Located in cortical cytoskeleton; membrane; and sarcomere. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; musculature; and sensory organ. Used to study dilated cardiomyopathy. Orthologous to human TMOD1 (tropomodulin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmod1 |
| Official Name | tropomodulin 1 [Source:MGI Symbol;Acc:MGI:98775] |
| Ensembl ID | ENSMUSG00000028328 |
| Bio databases IDs | |
| Aliases | tropomodulin 1 |
| Synonyms | D9S57E, ETMOD, E-TROPOMODULIN, TMOD, TROPOMODULIN, tropomodulin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tropomodulin
- actin binding
- tropomyosin binding
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- unspecified disease
- Alzheimer disease
- renal cell carcinoma
- renal cell cancer
- preeclampsia
- Barrett syndrome
- esophageal adenocarcinoma
- esophageal carcinoma formation
- cerebral aneurysm
role in cell
- formation
- adhesion
- formation in
- quantity
- striation
- degeneration
- morphology
- assembly
- width
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- central junction
- cortical cytoskeleton
- cytoskeleton
- cellular membrane
- Nucleus
- Plasma Membrane
- actin filaments
- sarcomere
- cytosol
- dendritic spine neck
- dendritic spine head
- growth cone
- myofibrils
- A bands
- thin filaments
- junctional complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- pointed-end actin filament capping
- muscle contraction
- actin filament organization
- adult locomotory behavior
- lens fiber cell development
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- cytoskeleton
- membrane
- cytosol
- signalosome
- actin filament
- sarcomere
- myofibril
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin binding
- tropomyosin binding