Hspb7 Gene Summary [Mouse]
Enables filamin binding activity. Predicted to be involved in heart development. Located in actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HSPB7 (heat shock protein family B (small) member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspb7 |
| Official Name | heat shock protein family, member 7 (cardiovascular) [Source:MGI Symbol;Acc:MGI:1352494] |
| Ensembl ID | ENSMUSG00000006221 |
| Bio databases IDs | |
| Aliases | heat shock protein family, member 7 (cardiovascular) |
| Synonyms | cvHSP, heat shock protein family B (small) member 7, heat shock protein family, member 7 (cardiovascular), Hsp25-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspb7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- alpha-crystallin Hsps/p23-like
- Hsp20/alpha crystallin family
- protein binding
Pathways
Biological processes and signaling networks where the Hspb7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertrophic cardiomyopathy
- congestive heart failure
- colon adenocarcinoma
- colon epithelial cancer
- survival
- uterine leiomyoma
- leiomyomatosis
- dilated cardiomyopathy
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- invasion by
- proliferation
- migration
- expression in
- abnormal morphology
- mineralization
- osteogenic differentiation
- production in
- aggregation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- actin cytoskeleton
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspb7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- regulation of heart contraction
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- actin cytoskeleton
- Cajal body
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- filamin binding