Ssrp1 Gene Summary [Mouse]
Enables chromatin binding activity. Predicted to be involved in nucleosome disassembly and regulation of chromatin organization. Predicted to be located in nucleus. Predicted to be part of FACT complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ssrp1 |
| Official Name | structure specific recognition protein 1 [Source:MGI Symbol;Acc:MGI:107912] |
| Ensembl ID | ENSMUSG00000027067 |
| Bio databases IDs | |
| Aliases | structure specific recognition protein 1 |
| Synonyms | C81323, FACT, FACT80, Hmg1-rs1, Hmgi-rs3, Hmgox, Preiibf, structure specific recognition protein 1, T160 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ssrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- chromatin binding
- protein binding
- Pleckstrin homology-like domain
- POB3-like N-terminal PH domain
- DNA binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- p63 binding domain
- basic domain
- Structure-specific recognition protein (SSRP1)
- Histone chaperone Rttp106-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pleural mesothelioma
- mesothelioma formation
- ovarian cancer
role in cell
- apoptosis
- activation in
- cell death
- growth
- expression in
- cell viability
- number
- binding
- organization
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- microtubules
- midbody
- nucleoplasm
- nucleoli
- spindle fibers
- astral microtubules
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ssrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- FACT complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- histone binding
- nucleosome binding