Tmem176b Gene Summary [Mouse]
Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TMEM176B (transmembrane protein 176B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem176b |
| Official Name | transmembrane protein 176B [Source:MGI Symbol;Acc:MGI:1916348] |
| Ensembl ID | ENSMUSG00000029810 |
| Bio databases IDs | |
| Aliases | transmembrane protein 176B |
| Synonyms | 1810009M01Rik, Clast1, LR8, MS4B2, Torid, transmembrane protein 176B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem176b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- CD20-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- AKT
- ERK1/2
disease
- neoplasia
- metabolic syndrome X
- serous ovarian adenocarcinoma
- serous ovarian cancer
- peripheral arterial disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- lung adenocarcinoma
- lung adenocarcinoma formation
- Ullrich congenital muscular dystrophy
role in cell
- differentiation
- invasion
- transformation
- differentiation by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem176b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- negative regulation of dendritic cell differentiation
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
Molecular Function
What the gene product does at the molecular level
- protein binding