Wdr54 Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization; negative regulation of receptor internalization; and regulation of signal transduction. Predicted to be located in several cellular components, including intracellular membrane-bounded organelle; plasma membrane; and vesicle. Predicted to be active in motile cilium. Orthologous to human WDR54 (WD repeat domain 54). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr54 |
| Official Name | WD repeat domain 54 [Source:MGI Symbol;Acc:MGI:1922909] |
| Ensembl ID | ENSMUSG00000030032 |
| Bio databases IDs | |
| Aliases | WD repeat domain 54 |
| Synonyms | 1700030E05Rik, LOC103692166, RGD1561494, WD repeat domain 54 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr54 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr54 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- negative regulation of receptor internalization
- cilium morphogenesis
- regulation of epidermal growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- vesicle
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity