Pfkp Gene Summary [Mouse]
Predicted to enable 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and urinary system. Orthologous to human PFKP (phosphofructokinase, platelet). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pfkp |
| Official Name | phosphofructokinase, platelet [Source:MGI Symbol;Acc:MGI:1891833] |
| Ensembl ID | ENSMUSG00000021196 |
| Bio databases IDs | |
| Aliases | phosphofructokinase, platelet |
| Synonyms | 1200015H23Rik, 9330125N24Rik, ATP-PFK, PFK-C, PFKF, Phosphofructokinase 1 C, Phosphofructokinase, platelet, Phosphohexokinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pfkp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 6-phosphofructokinase, eukaryotic type
- binding protein
- 6-phosphofructokinase
- ATP binding
- protein binding
- PFK
- identical protein binding
- phosphofructokinase
Pathways
Biological processes and signaling networks where the Pfkp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- colorectal cancer
- colon adenocarcinoma
- gastric cancer
- rectum cancer
- gastric adenocarcinoma
- lung cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- androgenic alopecia
role in cell
- invasion by
- expression in
- proliferation
- colony formation by
- glycolysis in
- Gap 0-Gap 1 phase
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pfkp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- 6-phosphofructokinase complex
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- fructose-6-phosphate binding
- AMP binding
- metal ion binding
- cadherin binding
- monosaccharide binding
- 6-phosphofructokinase activity