Lrfn1 Gene Summary [Mouse]
Predicted to be involved in regulation of postsynaptic density assembly. Located in cell surface. Is expressed in several structures, including branchial arch; central nervous system; dorsal root ganglion; limb; and sensory organ. Orthologous to human LRFN1 (leucine rich repeat and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrfn1 |
| Official Name | leucine rich repeat and fibronectin type III domain containing 1 [Source:MGI Symbol;Acc:MGI:2136810] |
| Ensembl ID | ENSMUSG00000030600 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and fibronectin type III domain containing 1 |
| Synonyms | BC004018, leucine rich repeat and fibronectin type III domain containing 1, LOC100911296, SALM2, Semo1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrfn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Leucine rich repeat
- protein binding
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- Plasma Membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrfn1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- plasma membrane
- cell surface