Stx1b Gene Summary [Mouse]
Enables protein kinase binding activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of synaptic vesicle recycling; and neurotransmitter secretion. Located in axon; plasma membrane; and presynapse. Is active in neuromuscular junction and presynaptic active zone membrane. Is expressed in forebrain; hindlimb; and retina layer. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx1b |
| Official Name | syntaxin 1B [Source:MGI Symbol;Acc:MGI:1930705] |
| Ensembl ID | ENSMUSG00000030806 |
| Bio databases IDs | |
| Aliases | syntaxin 1B |
| Synonyms | GEFSP9, LOC100129076, STX1B1, STX1B2, Stx1bl, Stx2, Syn1b, syntaxin 1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SynN
- protein kinase binding
- cytoplasmic domain
- SNARE domain
- Helical region found in SNAREs
- Syntaxin
- protein domain specific binding
- protein binding
- receptor binding
- SNARE motif
Pathways
Biological processes and signaling networks where the Stx1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- generalized epilepsy with febrile seizures plus type 9
- psoriasis
- hereditary disorder
- neuroticism
- generalized epilepsy with febrile seizures plus
- neurodevelopmental disorder
- generalized epilepsy
regulates
- neurotransmitter
- L-glutamic acid
- SNARE
- STX1B
role in cell
- cell viability
- assembly in
- priming
- docking
- abnormal morphology
- exocytosis by
- turnover
- exocytosis
- abnormal quantity
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane fractions
- membrane fraction
- Cytoplasm
- presynaptic regions
- cellular membrane
- Nucleus
- centrosome
- cytosol
- presynaptic membrane
- nucleoplasm
- nuclear lamina
- neuromuscular junctions
- transport vesicles
- axons
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
- synaptic vesicle docking involved in exocytosis
- calcium ion-dependent exocytosis of neurotransmitter
- regulation of synaptic vesicle priming
- vesicle fusion
- negative regulation of neuron projection development
- vesicle docking
- vesicle docking involved in exocytosis
- synaptic vesicle fusion to presynaptic membrane
- positive regulation of neurotransmitter secretion
- regulation of gene expression
- positive regulation of excitatory postsynaptic membrane potential
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- membrane
- spindle
- endomembrane system
- SNARE complex
- cytosol
- neuromuscular junction
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- SNAP receptor activity
- SNARE binding
- receptor binding