Sergef Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of protein secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; esophagus; and ganglia. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sergef |
| Official Name | secretion regulating guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1351630] |
| Ensembl ID | ENSMUSG00000030839 |
| Bio databases IDs | |
| Aliases | secretion regulating guanine nucleotide exchange factor |
| Synonyms | DELGEF, Gef, Gnef, Gnefr, RGD1563497, secretion regulating guanine nucleotide exchange factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sergef often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- guanyl-nucleotide exchange factor
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sergef gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein secretion
- signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity