Ate1 Gene Summary [Mouse]
Enables arginyl-tRNA--protein transferase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within protein arginylation. Located in cytoplasm and nucleus. Is expressed in several structures, including embryo mesenchyme; eye; heart; nervous system; and notochord. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ate1 |
| Official Name | arginyltransferase 1 [Source:MGI Symbol;Acc:MGI:1333870] |
| Ensembl ID | ENSMUSG00000030850 |
| Bio databases IDs | |
| Aliases | arginyltransferase 1 |
| Synonyms | arginyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ate1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arginine-tRNA-protein transferase, C terminus
- arginyltransferase
- Arginine-tRNA-protein transferase, N terminus
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- SNCA
- EAhy926 cells
disease
- schizophrenia
- glioblastoma
- glioblastoma cancer
- breast cancer
- congenital heart disease
- prostate cancer
- breast carcinoma
- scarlet fever
- bleeding
- diverticular disease
phenotypes
- abnormal blood vessel morphology
- abnormal heart atrium morphology
- abnormal intercalated disk morphology
- abnormal myocardial fiber morphology
- abnormal myocardial fiber physiology
- abnormal vascular regression
- atrial septal defect
- decreased cardiac muscle contractility
- embryonic growth arrest
- hemorrhage
- lethality throughout fetal growth and development complete penetrance
- lethality throughout fetal growth and development incomplete penetrance
- pallor
- persistent truncus arteriosis
- skin edema
- slow postnatal weight gain
- thin myocardium
- ventricle myocardium hypoplasia
- ventricular septal defect
role in cell
- expression in
- migration
- apoptosis
- activation in
- number
- binding
- phosphorylation in
- formation
- stabilization in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ate1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein arginylation
- proteasomal protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- arginyltransferase activity