Exoc2 Gene Summary [Mouse]
Enables small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; regulation of entry of bacterium into host cell; and vesicle docking involved in exocytosis. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and palatal shelf. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc2 |
| Official Name | exocyst complex component 2 [Source:MGI Symbol;Acc:MGI:1913732] |
| Ensembl ID | ENSMUSG00000021357 |
| Bio databases IDs | |
| Aliases | exocyst complex component 2 |
| Synonyms | 2410030I24Rik, AL645745.1, exocyst complex component 2, Gm29675, LOC103689971, NEDFACH, Rsec5, SEC5, SEC5L1, Sec5p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exoc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- IPT
- Ral binding domain
- IPT/TIG domain
- enzyme binding
- protein binding
- Vps51/Vps67
- transporter
Pathways
Biological processes and signaling networks where the Exoc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- sunburn
- epithelial cancer
- glaucoma
- hemorrhoid
- neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia
- dental caries
- open-angle glaucoma
- psoriasis
- complex neurodevelopmental disorder
role in cell
- survival
- growth
- binding in
- apoptosis
- formation by
- cell-to-cell spreading by
- ruffling
- degranulation
- autophagy by
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insulin granule
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exoc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- cytokinesis after mitosis
- protein transport
- vesicle docking involved in exocytosis
- Golgi to plasma membrane transport
- regulation of entry of bacterium into host cell
- exocytosis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- small GTPase binding